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Network systems biology – the study of the spatiotemporally dynamic physical and functional interactions of biomolecules in diverse complex biological systems that are crucial to human health and disease – is an emerging strength at the OHSU Knight Cancer Institute. Elucidating the biological networks that drive cancer development and metastatic pathology is fundamental to a deeper mechanistic understanding of neoplastic processes and their causal links to drug resistance and clinical outcomes. Network systems biology is expected to drive cancer research in the coming decades. The CNSB, led by Prof. Andrew Emili, aims to implement innovative spatial proteomics and functional proteomics strategies to advance the field.
