Research Innovative Multidisciplinary Strategies at CNSB

CNSB generates holistic ‘interactome’ maps that reveal the roles and associations of protein complexes relevant to human health and disease: particular attention is focused on elucidating how these networks are altered in cancer and other pathological cellular states.

Together with our expert partners, members of the CNSB then perform stringent, in-depth follow-up studies to verify the functional significance of some of the key macromolecules that we discover.

As part of our ongoing service to the broader research community, CNSB engages in outreach and training to enable next generation technology and skills dissemination.

CNSB’s innovative tools, training, and datasets serve as valuable resources for the US scientific community. By supporting an outstanding team of scientists at the forefront of network systems biology, CNSB aims to advance basic understanding of cancer and other diseases and translate that knowledge into improved clinical treatments.

High impact publications

The CNSB produces highly cited research findings that are widely disseminated via our dedicated web portals and public databases.

Our team has published over 300 peer-reviewed papers, including 75 in the past 5 years alone, which have garnered over 40,000 citations to date. These include first-in-class proteome-scale interaction maps for model organisms and human cancer cells.

Notable publications by center members include:

SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer

Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins.

Innovative Multidisciplinary Strategies